Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants.

Guidetti, C., Papakostas, G. I., Stahl, S., Pani, L., De Martin, S., Mattarei, A., Comai, S., Kröger, C., Champasa, P., Gorodetzky, C. W., Vocci, F. J., Kosten, T. R., Bushnell, D., Kappler, M., Folli, F., Inturrisi, C. E., Pappagallo, M., Manfredi, P. L., & Fava, M. (2026). Depression severity and efficacy outcomes: post hoc analyses from a phase 3 trial of esmethadone for the adjunctive treatment of major depressive disorder with inadequate response to standard antidepressants. International clinical psychopharmacology, 41, (4), 213–224. https://doi.org/10.1097/YIC.0000000000000618