FRI is pleased to announce that Drs. Karen Alexander and Jan Gryczynski (MPIs) have received funding from the National Institute on Drug Abuse for their project “Implementing a patient navigation intervention across a health system to improve outcomes for patients with opioid use disorder.” The project represents a transition from formative work conducted over the past two years, into a full-scale implementation-effectiveness trial of the Navigation Services to Avoid Rehospitalization (NavSTAR) intervention. The study will deploy the intervention at five hospitals in the Jefferson Health system in Philadelphia, an epicenter of the opioid crisis, using a stepped-wedge design. Drs. Alexander and Gryczynski are joined by Co-Investigators Drs. Courtney Nordeck and Mishka Terplan (FRI) and Drs. Megan Reed, Kory London, Phil Durney, Serge-Emile Simpson, and Amanda Kingston (Thomas Jefferson University). This type II hybrid-implementation-effectiveness trial (N=720) will develop an effective strategy to increase the reach and sustainability of NavSTAR and provide a path to scale up this intervention in a real-world setting, measuring patient-level and implementation outcomes.